11 Aug 2016
Neurodegenerative diseases including Alzheimer’s and Parkinson’s diseases can cripple lives to varying degrees: from minor disability to loss of movement or memory. At present, there are no ultimate cures to these diseases. Research in neural stem cell and regenerative medicine using functional neural stem cells from adult human brain is currently hindered due to risks with brain surgery and the uncertainty in the location of extraction. We demonstrate for the first time that a novel harvest method for the neural stem cells from choroid plexus lining along the subventricular zone by applying antibodies conjugated magnetic iron oxide nanoparticles (Ab-MNPs) to the corresponding region in a rat brain (Lui et al., 2013). It is shown that the magnetically isolated but active stems cells can be developed into neurospheres and differentiated into different types of cells in culture medium in vitro. The cells can then be re-applied to the same subject for treatment. This autologous approach leads us to develop a new tailor-made personalized autologous cell replacement therapy for patients with neurodegeneration. As the cells are originated from the patients themselves, the risk of immuno-rejection can be greatly reduced. This approach can therefore greatly enhance the chance for treating neurodegeneration.
References
Lui et al. (2013). Neural stem cells harvested from live brains by antibody-conjugated magnetic nanoparticles. Angew Chem Int Ed Engl. 18;52(47):12298-12302
Keywords: Neural Stem Cells, Alzheimer, Parkinson, neurodegeneration, autologous cell replacement therapy
Conference: 14th Meeting of the Asian-Pacific Society for Neurochemistry, Kuala Lumpur, Malaysia, 27 Aug - 30 Aug, 2016.
Presentation Type: Symposium 11: Generating New Neurons: From Development to Cell-Based Therapy
Topic: 14th Meeting of the Asian-Pacific Society for Neurochemistry
Citation: Yung KK and Lui CN (2016). Neural stem cell harvest from live adults: A novel approach for autologous cell replacement therapy. Conference Abstract: 14th Meeting of the Asian-Pacific Society for Neurochemistry. doi: 10.3389/conf.fncel.2016.36.00046
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Received: 26 Jul 2016; Published Online: 11 Aug 2016.
* Correspondence: Prof. Ken K Yung, Hong Kong Baptist University, Department of Biology, Hong Kong, Hong Kong SAR, China, kklyung@hkbu.edu.hk